Keywords
Abstract
In gastropathies induced by indomethacin, the effects of several pharmacological agents on lipid peroxidation parameters and the state of the antioxidant system in the gastric mucosa were investigated. The levels of acyl hydroperoxides and malondialdehyde were determined as markers of oxidative stress, along with the activity of key antioxidant enzymes, catalase and superoxide dismutase. The results demonstrated that all studied drugs exerted comparable effects on the intensity of lipid peroxidation processes and the functional activity of antioxidant defense enzymes in the gastric mucosa. At the same time, it was established that Lesbokhol, a combination of plant extracts, exhibits more pronounced pharmacological activity compared to Mucogen (rebamipide) and misoprostol. The observed effects indicate the potential usefulness of Lesbokhol in the correction of indomethacin-induced gastropathies and confirm its higher antioxidant potential.