Abstrak
Aholining umr ko‘rish davomiyligi ortib borayotgani tufayli menopauza davridagi ayollar soni yildan-yilga ko‘paymoqda. Mazkur davr ayol organizmida endokrin, metabolik, vegetativ va psixoemotsional o‘zgarishlar bilan kechadi. Klimakterik sindrom esa menopauzaning eng ko‘p uchraydigan klinik ko‘rinishlaridan biri bo‘lib, uning og‘irligi ayolning kundalik faoliyati, mehnat qobiliyati hamda hayot sifatiga sezilarli ta'sir ko‘rsatadi. So‘nggi yillarda klimakterik sindromning patogenezi, xavf omillari va baholash mezonlarini takomillashtirish bo‘yicha ko‘plab ilmiy izlanishlar olib borilgan bo‘lsa-da, klinik amaliyotda individual yondashuvni ishlab chiqish dolzarbligicha qolmoqda [1,3].
References
Davis SR, Baber R, Panay N, Bitzer J, Perez SC, Islam RM, et al. The 2023 Practitioner’s Toolkit for Managing Menopause. Climacteric. 2023;26(6):517–536.
National Institute for Health and Care Excellence (NICE). Menopause: Identification and Management (NG23). London: NICE; Updated 2024.
Hamoda H, Moger S, Morris E, Baldeweg SE, Kasliwal A, Gabbay F, et al. Menopause practice standards. Clin Endocrinol (Oxf). 2024;100(1):50–55.
Hemachandra C, Taylor S, Islam RM, Fooladi E, Davis SR. A systematic review and critical appraisal of menopause guidelines. BMJ Sex Reprod Health. 2024;50(2):122–138.
International Menopause Society. IMS Recommendations and Key Messages on Women's Midlife Health and Menopause. 2025.
The Menopause Society. 2023 Nonhormone Therapy Position Statement. Menopause. 2023.
The Menopause Society. The 2022 Hormone Therapy Position Statement. Menopause. 2022.
The Menopause Society. Genitourinary Syndrome of Menopause Position Statement. Menopause. 2020;27(9):976–992.
Lega IC, et al. A pragmatic approach to the management of menopause. CMAJ. 2023;195:E667–E677.
Alves JMP, Neves DBS. Assessment instruments for climacteric syndrome: an integrative review. Rev Científica Integrada. 2023.
Geukes M, van Aalst MP, Nauta MC, Oosterhof H. The impact of menopausal symptoms on quality of life. Maturitas. 2018;114:55–61.
World Health Organization. Obesity: Preventing and Managing the Global Epidemic. Geneva: WHO.
Schneider HPG, Heinemann LAJ, Rosemeier HP, Potthoff P, Behre HM. The Menopause Rating Scale (MRS): reliability and validity.
Heinemann LAJ, et al. The Menopause Rating Scale: a methodological review.
Rosner B. Fundamentals of Biostatistics. 9th ed. Boston: Cengage Learning; 2021.
World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. 2018 update.
Santoro N, Epperson CN, Mathews SB. Menopausal symptoms and their management. Endocrinol Metab Clin North Am. 2021.
Thurston RC, Joffe H. Vasomotor symptoms and menopause. Lancet. 2021.
Davis SR, Lambrinoudaki I, Lumsden M, et al. Menopause. Nat Rev Dis Primers. 2018.
Baber RJ, Panay N, Fenton A. IMS Recommendations on women's midlife health. Climacteric. 2020.
Avis NE, Crawford SL, Greendale G, et al. Duration of menopausal vasomotor symptoms. JAMA Intern Med.
Joffe H, Thurston RC. Biology of menopausal sleep disturbances. Sleep Medicine Clinics.
Santoro N. The menopausal transition: physiology and clinical implications. J Clin Endocrinol Metab.
Muka T, Oliver-Williams C, Kunutsor S, et al. Association of age at menopause and cardiovascular disease. JAMA Cardiology.
Davis SR, Baber RJ. Menopause and healthy ageing. Climacteric.
Zhu D, Chung HF, Pandeya N, et al. Body mass index and menopausal symptoms: systematic review and meta-analysis. Obesity Reviews.
Islam RM, Bell RJ, Green S, et al. Safety and effectiveness of menopausal hormone therapy. The Lancet Healthy Longevity.
Panay N, Baber RJ. Current concepts in menopausal management. Climacteric.
European Menopause and Andropause Society (EMAS). Clinical guide to menopausal management.
Canadian Menopause Society. Menopause Management Pocket Guide. 2024.